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Research:

The central goal of our research is to characterize how proteases regulate important biological processes such as apoptosis and cell differentiation. For example, the dysregulation of caspases underlies several human diseases that include cancer and inflammatory disorders, and a better understanding of these enzymes is of great importance in order to design new therapies. Using functional proteomics approaches, our lab focus on characterizing how protease substrates play critical roles in such vital processes, to advances our knowledge about the role of these proteases in human diseases. Harnessing recent progress in cellular engineering, we take advantage of tools such as CRISPRi technology and antibody engineering to further support our proteomics findings.

Selected Publications:

Hartley B, Bassiouni W, Roczkowsky A, Fahlman R, Schulz R, Julien O 
J. Proteome Research. (2024) 23:844-856

Gomez-Cardona E, Eskandari-Sedighi G, Fahlman R, Westaway D, Julien O 
ACS Chemical Neuroscience. (2024) 15:134-146

Luo SH, Moussa E, Ishida R, Orozco-Lopez J, Wang H, Wilson J, Kumar A, Hobman T, Julien O 
ACS Infectious Diseases (2023) 9:749-61  

Araya LE, Soni IV, Hardy J, Julien O 
ACS Chem. Biol. (2021) 16:2280-2296  

Luo SH, Araya LE, Julien O 
ACS Chem. Biol. (2019) 14:2361-2371  

Hill ME, Kumar A, Wells JA, Hobman TC, Julien O, Hardy JA.
ACS Chem Biol. 2018 Aug 14. doi: 10.1021/acschembio.8b00508. [Epub ahead of print]

Julien O, Wells JA.
Cell Death Differ (2017) 24:1380-1389