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Research:

The laboratory is focused on elucidating the molecular mechanisms involved in the initiation of immune responses when the organism is challenged with pathogens. We are using new imaging technologies, capable of resolving the behaviour of single molecules, to define the change of state overtime that receptors of innate immune cells (macrophages and dendritic cells) are undergoing during their interaction with pathogen's molecules.

Selected Publications:

Wang H, Wei E, Quiroga AD, Sun X, Touret N.
Lehner R. Mol Biol Cell. (2010) Jun 15; 21(12):1991-2000.

Koivusalo M, Welch C, Hayashi H, Scott CC, Kim M, Alexander T, Touret N, Hahn KM, Grinstein S.
J Cell Biol. (2010) Feb 22; 188(4):547-63.

Steinberg BE, Touret N, Vargas-Caballero M, Grinstein S.
PNAS. (2007) May 29;104(22):9523-8.

Martin-Orozco N, Touret N, Zaharik ML, Park E, Kopelman R, Miller S, Finlay BB, Gros P, Grinstein S.
Mol Biol Cell. (2006) Jan;17(1):498-510.

Touret N, Paroutis P, Terebiznik M, Harrison R, Trombetta S, Pypaert M, Chow A, Jiang A, Shaw J, Yip C, Moore HP, van der Wel N, Houben D, J. Peters PJ, de Chastellier C, Mellman I and Grinstein S.
Cell. (2005) Oct 7;123(1):157-70.